Organisotypic culture as a model for aging-associated diseases
The aging process is a major risk factor in a number of diseases and causes of death. The aging process and diseases it causes are multifactorial. There are many contributing factors, as well as phenotypes, at the cellular, tissue and organismal levels. The models used for aging research are limited despite the complexity of aging. In vivo models are often genetically modified to mimic late disease phenotypes, rather than the early causes. In vitro models are often used, but they lack the complex systemic and tissue-scale cues disrupted by aging.