Unlocking Placental Stem cells for Heart Regeneration

Researchers find placental stem cell that can regenerate the heart after a heart attack

Researchers from Mount Sinai’s Icahn School of Medicine have shown that Cdx2 stem cells, derived directly from the placenta, can regenerate healthy cells in the heart after a heart attack. These findings were published in the Proceedings of the National Academy of Sciences issue of May 20, which may be a new treatment for regenerating the organs and heart.

This is exciting because Cdx2 cells were previously thought to be able to only regenerate the placenta during early embryonic development. But this discovery has never been made before. The findings could also pave the path to regenerative therapies for other organs than the heart,\” said Hina Chaudhry MD, principal investigator and Director of Cardiovascular & Regenerative Medicine, Icahn Medical School at Mount Sinai. They are almost like a super-charged stem cell population, as they travel directly to an injury site through the circulatory systems and avoid rejection by the immune system.

Mount Sinai researchers discovered previously that a mixed population mouse placental cells could help pregnant female mice’s hearts recover from an injury which would otherwise cause heart failure. In the study, the researchers showed that placental cells moved to the mother’s lungs and then directly to the location of the injury. The stem cells were then programmed to become beating heart cells in order to aid the repair process.


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