Unveiling Human Skeletal Muscle Development Pathway: A Roadmap for Regenerative medicine

Scientists develop first human muscle development roadmap

Researchers at UCLA’s Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have developed the first-ever roadmap for how human skeletal muscles develop, including the formation and function of muscle stem cells.

Cell Stem Cell is a peer-reviewed scientific journal that published the study. It identified different cell types in skeletal muscles, from the early stages of embryonic development to adulthood. The group focused on muscle progenitor and stem cells that contribute to the formation of muscle before birth. They also looked at how these cells contribute to the formation of muscle after birth as well as to the regeneration from injuries throughout life.

Researchers who want to use muscle stem cells for regenerative cell therapy for muscle diseases such as muscular dystrophies and sarcopenia (age-related loss in muscle strength and mass) will need the roadmap.


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