Unlocking the Secrets of Cellular Mechanisms that Regulate Aging and Fertility

Scientists discover a novel cell mechanism that regulates fertility and aging

The research at the Institute of Molecular Biology and Biotechnology of the Foundation for Research and Technology-Hellas, published today in Nature Aging, reveals a basic quality control mechanism in cells that safeguards the integrity and functionality of the nucleus. This molecular mechanism promotes longevity and fertility by maintaining nuclear homeostasis.

Researchers at the IMBB, Dr. Margarita Elena Papandreou, Dr. Georgios Constantinidis and Dr. Nektarios Tártarakis, led by Dr. Nektarios Tártarakis (Professor of the Medical School of the University of Crete and Chairman of the Board of FORTH), have discovered that recycling of nucleolar and nuclear components via autophagy delays aging of cells and maintains the immortality of sperm

The nucleus, the central organelle in all eukaryotic cellular organisms, contains genetic material (DNA), determining cellular identity and functions. The ultrastructure of nuclei is altered dramatically during aging, and also in cancer cells. The nuclear architecture shows a progressive and marked deterioration, which is characteristic of progeria as well as many other disorders that are associated with ageing.


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