Unlocking the potential of supercentenarian cellular reprogramming

Reprogramming the Cells of a Supercentenarian is a Success

Researchers from AgeX Therapeutics, as well as other organizations, have proven that it is possible to reprogramme banked stem cells from a supercentenarian. The discovery opens up exciting new opportunities for research into aging.

What is cellular reprograming?

Cellular reprogramming involves converting mature, specialized stem cells into induced pluripotent stem cells (iPSCs), that can be developed into any type of cell found in the body. In 2006, Drs. Takahashi & Yamanaka achieved this remarkable result by overexpressing only four genes: Oct4, Sox2, c-Myc, Klf4, c-Sox (OSKM), and clf4 (OSKM). These genes became known collectively as the Yamanaka Factors. Yamanaka received the Nobel Prize for this breakthrough in 2012. Yamanaka named these cells iPSCs – with a small “i” – as a reference to the iPod or similar devices.


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