Unlocking the Longevity Potential: Investigating the Genetics of Supercentenarians and Semi-Supercentenarians

Genetic mutations that prevent DNA damage in people who live beyond 105 years of age are present in those who have lived past this age.

It may be their genes that are responsible for people living to a very advanced age. Genetic variants that help to prevent DNA mutations and repair any that do occur have been found in supercentenarians and semi-supercentenarians – people who reach the ages of 110 and 105, respectively.

Claudio Franceschi, an Italian professor at the University of Bologna, says that DNA repair mechanisms in these individuals are very efficient. It is one of the main mechanisms that extends lifespan.


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