Unlocking Potential of Chemical Reprogramming in Stem Cell Generation

Make stem cells using chemicals
Reprogramming is possible without inserting genes.

When people talk about cellular reprogramming and converting a differentiated stem cell into a differentiated cell, they refer to the overexpression Yamanaka factors[Oct4, Sox2, c-Myc & Klf4]. It’s a good thing. What if I told you stem cells can be induced using only chemicals? You would say \”show me the results\”. Let’s look at a recent Nature article that shows how small molecules/chemicals can convert human differentiated stem cells.

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Reprogramming small molecules — 00:00
What does this tell us? — 04:45
Outlook — 08:35

Guan, J., Wang, G., Wang, J. et al. Chemical reprogramming human somatic cell into pluripotent cells. Nature 605325-331 (2022). https://doi.org/10.1038/s41586-022-04593-5
Kim, Y., Jeong, J. & Choi, D. Small-molecule-mediated reprogramming: a silver lining for regenerative medicine. Exp Mol Med 52213-26 (2020). https://doi.org/10.1038/s12276-020-0383-3

Please note that The Sheekey Show is separate from Eleanor Sheekey’s teaching and researching roles at the University of Cambridge. This show does not provide medical advice. It should also not be used to replace medical advice. The Sheekey Science Show, its guests and staff assume no responsibility for the use of information presented.

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