Unlocking Itaconate’s Power: A Promising Switch for Inflammation and Aging

Scientists find promising switch for inflammation
Inflammation is one of three main ageing processes.

Scientists discovered that a metabolic process within the body can turn off inflammation. Scientists have found that the molecule \”itaconate\”–derived from glucose –acts as an off-switch to macrophages. These cells are at the core of many inflammatory conditions, including arthritis, inflammatory heart disease, and inflammatory bowel diseases.

Scientists at Trinity College Dublin’s Trinity Biomedical Sciences Institute, School of Biochemistry and Immunology, hope that their discoveries will be relevant for infectious and inflammatory diseases. They also hope that their findings can help develop new drugs needed to treat these conditions.

Luke O’Neill is a Professor of Biochemistry in Trinity. He was the co-leader of this work, which has just been published by the leading international journal Nature. Both human cells and mouse model organisms were used to make the discoveries.


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