Uncovering the Sexual-Lineage-Specific Epigenetic Signature for Meiotic Regulation in Arabidopsis thaliana

Sexual-lineage-specific DNA methylation regulates meiosis in Arabidopsis
Year 2017 This is the basic mechanism for plant immortality.

The male lineage of Arabidopsis, thaliana, has a high level of RNA-directed DNA (RdDM), which regulates the expression of genes in meiocytes. Loss of sexual-lineage-specific RdDM causes mis-splicing of the MPS1 gene (also known as PRD2), thereby disrupting meiosis. Our results establish a regulatory paradigm in which de novo methylation creates a cell-lineage-specific epigenetic signature that controls gene expression and contributes to cellular function in flowering plants.


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