Uncovering the impact of aging on the genome: A study on mouse tissue

Understanding the effects of aging on genome

Fans of longevity research may enjoy this.

Aging is our greatest enemy. What is happening on the molecular and cellular level can be seen in our graying hair, waning strength, and age-related illnesses. Understanding the impact of aging on all cells of our body tissues will be invaluable in combating this enemy that is ephemeral.

It is important to observe and measure first. Scientists led by Johan Auwerx from EPFL asked a simple question in a Cell Reports paper: How do tissues of aging mouse differ from those of adult mice?

The researchers used multiple techniques to answer the question. They measured the expression of each of the mouse’s thousands of genes and identified any epigenetic differences. Researchers measured information in three different tissues, including liver, heart and muscle.


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