The role of Klotho for muscle regeneration: a study on young blood and aged muscle cells

The study identified a factor in \”young blood\” that rejuvenates aged mouse muscles

As we age, the muscles in our body become weaker, smaller and less able heal from injury. Researchers from UPMC, University of Pittsburgh and the National Institutes of Health have identified a key mediator of youth in mouse muscles. This discovery could lead to new muscle regeneration treatments for older people.

The study, published today in Nature Aging, demonstrates that circulating shuttles known as extracellular vesicles (EVs) deliver genetic instructions for longevity protein Klotho to muscles cells. The EVs in older mice that carry fewer copies than in younger animals may be responsible for the loss of muscle function in old mice.

These findings provide a new understanding of why muscle regeneration capacity decreases with age.


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