Cellular Senescence and Cardiovascular and Metabolic Diseases
We wanted to draw your attention today to a recent open-access paper. Authors review the role of cell senescence within the context of cardiovascular and metabolic diseases associated with aging. This paper focuses on the aging vascular system, and the role that an increasing number of senescent cell play in this process.
What is cellular ageing?
As we age, more and more cells are in a state called senescence. Senescent cells do not divide or support the tissues of which they are a part; instead, they emit a range of potentially harmful signals known collectively as the senescence-associated secretory phenotype (SASP). Senescent cells are normally destroyed by a process called apoptosis and removed by the body’s immune system. However, as the immune systems weaken with age, more senescent cell buildup occurs.