Parabiosis – the Dilution Solution
Scientists have been amazed by the rejuvenating effect of heterochronic parbiosis for a long time. Scientists have long been fascinated by the rejuvenating effects of heterochronic parabiosis. When the blood from a young and old mouse is mixed, the older mouse recovers certain features of youth while the younger mouse becomes functionally older. Many have assumed that this effect was driven by the infusion pro-youth factor from the younger parabiont to the older one. However, the \”Dilution Solution Hypothesis\” is also possible. This hypothesis suggests that the young blood dilutes pro-aging factors and allows the liver and kidneys of the young animal to filter out toxic metabolic waste.
The older mouse will regain some youthful characteristics when the circulatory system of the young mice is joined with that of the old. It is widely believed that pro-youth blood factors are responsible for the effect, but there is another possibility: the procedure could dilute pro-aging factors within the older partner.