Reversing the clock: Cellular Rejuvenation Therapy successfully delays aging in mice

The Cellular Rejuvenation Therapy safely reverses the signs of ageing in mice

The mice were treated with Yamanaka factors between 15 and 22 months of age, which is approximately the equivalent of 50 to 70 years in humans. A second group received treatment from 12 to 22 months (roughly equivalent to age 35-70 in humans). A third group, aged 25 months (similar to human age 80), was only treated for one month.

LA JOLLA –(March 7, 2022) Age is just a number. But it can have unwanted effects. These include brittle bone and weak muscles, as well as increased risk of cancer and cardiovascular disease. Scientists at the Salk Institute in collaboration with Genentech (a member of Roche group) have demonstrated that they can safely reverse the aging processes in middle-aged or elderly mice by partially resetting their cells to a more youthful state.

\”We’re thrilled that we can apply this approach to normal animals throughout their lives and slow down the aging process.\” Juan Carlos Izpisua Belmonte is a professor at Salk’s Gene Expression Laboratory and co-corresponding author. He says that the technique has been shown to be both safe and efficient in mice. This approach could be used to improve cell function and resilience to treat different diseases such as neurodegenerative disease.


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