Reversing Age-Associated Skin Wrinkles in a Mice Model

Scientists reverse wrinkles in the skin and hair loss associated with aging using a mouse model

BIRMINGHAM (Ala.) — Aging is characterized by wrinkled skin and hair loss. What if these signs of aging could be reversed.

Keshav Singh and his colleagues at the University of Alabama at Birmingham have achieved this in a mouse-model developed by them. In a few weeks, a mouse with a mitochondrial dysfunction mutation develops wrinkled, balding skin. The mouse’s smooth skin and thick hair return when the mitochondrial function of the gene is turned off.

Singh, professor of genetics at the UAB School of Medicine, said that this was a first-ever observation.


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