The method turns the clock back on old human cell
Researchers studied patterns of chemical tags that indicate a cell’s chronological aging, called methyl groups. They found that treated cells were on average 1 1/2-3 1/2 years younger than cells of elderly people that had not been treated, with peaks at 3 1/2 (in skin cells), and 7 1/2 (in blood vessel cells).
The study showed that expressing these proteins briefly in old human cells in lab dishes reverses many molecular markers of aging, and makes the cells treated almost indistinguishable.
Vittorio Sebastiáno, senior author and assistant professor at Stanford University, explains that iPS stem cells can be made from adult skin cells.
We’ve been wondering for some time whether it is possible to simply turn back the clock on aging without inducing pluripotentity. We’ve discovered that by carefully controlling the duration of exposure to these proteins factors, we are able to promote rejuvenation across multiple types of human cells.