Medical Science Breakthrough: The creation of mice with hyper-long telomeres leads to increased longevity

Researchers have created the first mice with hyper-long Telomeres

Researchers at the Spanish National Cancer Research Centre CNIO were able to create the first mice with telomeres that were much longer than the norm for their species 10 years ago. Telomeres decrease with age, and older organisms will have shorter telomeres. Scientists based their study on the relationship between telomeres, aging and mice that had 100% of their cells with hyper-long telomeres. Nature Communications published the findings, which show that hyper-long telomeres have only positive effects: animals with these telomeres are healthier and live longer. They also do not suffer from cancer or obesity. It is the first time longevity has been increased significantly without genetic modification.

This finding confirms that genes are not the sole factor to be considered when determining life expectancy, says Maria Blasco. She is the head of the CNIO Telomeres and Telomerase Group and the intellectual author of this paper. There is a margin to extend life without changing the genes.

The telomeres are the ends of the chromosomes that reside in the nucleus in each cell of the body. They protect the integrity and genetic information of DNA. The telomeres are shortened when cells divide, and this is one of the characteristics of aging. In a Nature Communications paper, the authors state that \”Telomere Shortening is one of the main causes of aging\” because short telomeres reduce longevity and cause organisms to age.


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