Longevity Breakthrough – Increasing life expectancy in mice by 30%

Researchers have increased the life expectancy of mice by 30% on average

The aging process is linked to a decline in overall health, increased frailty and a higher risk of chronic diseases. More than 30% of elderly people suffer from frailty syndrome. This is characterized by fatigue, weakness and low levels of physical activity. To facilitate the development and implementation of interventions to improve health, survival and longevity, it is important to increase our understanding of the mechanisms that underlie the aging process.

Evidence suggests that diet, metabolism and exercise are the key regulators for a healthy lifespan. Prof. Haim Cohn, Director of Bar-Ilan University’s Sagol Healthy Human Longevity Center, focuses his research on SIRT6, a protein involved in regulating a number of biological processes such as aging and obesity.

According to a recent study published in Nature Communications by a team of international researchers led by Cohen, his Ph.D. Student Asael, and Rafael de Cabo of the National Institute on Aging of the National Institutes of Health along with Manuel Serrani of the Institute for Research in Biomedicine in Barcelona and Eyal Gottlieb of the Technion, transgenic mice have high levels of SIRT6 and their life expectancy has been increased by 30% on average for both men and women. In human terms, this means a 90-year old could live to nearly 120 years!


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