Identifying a New Protein Linked to Alzheimer’s Disease

A new protein that may contribute to Alzheimer’s disease has been identified

Alzheimer’s (AD) is an incurable, progressive disease that starts with mild memory loss. It slowly destroys memory and cognitive function. The disease is currently incurable and will affect more than 100 million people in the world by 2050. According to the National Institute on Aging, AD is the most common cause for dementia among older adults in the United States and the seventh leading cause of death.

The focus of Alzheimer’s research continues to be on amyloid beta and tau, two neurotoxic proteins. These proteins are associated with AD but their levels do not correlate or explain the severity of cognitive impairment in some patients with AD.

Researchers at Brigham and Women’s Hospital in Boston, Massachusetts, which is a founding member hospital of the Mass General Brigham Healthcare System, sought to identify proteins that could be directly linked with AD’s fundamental features, such as synaptic degeneration and neurodegeneration. The researchers exposed laboratory neurons with brain extracts of about 40 individuals who had AD or were protected against AD despite high Ab and Tau levels in their brains.


New Protein Identified That May Contribute to Alzheimer’s Disease

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