The SIRT6 gene therapy is based on the variants found in centenarians.
He explains that \”so many genes are involved with DNA maintenance. FOXO3 is an example. It’s very interesting but cannot be used as a therapeutic target, because it triggers a lot other things.\” \”SIRT6 codes for one protein. It’s small, and the cargo isn’t too large, making it a good target for gene therapy.\”
Leire says that some of the other factors in Genflow’s favor are the fact that we have a better understanding about the biology of ageing, and that gene therapy is also making great progress.