Fisetin, a new senolytic
A newly published study by Josh Mitteldorf provides more information about the search for natural senolytics, which can clear senescent cell and make us look younger. Ficetin is abundant in strawberries and other fruits. We would still need to eat around 20 kg of strawberries over two days in order to achieve the same dose as the mice who lived longer.
Since the groundbreaking paper published by van Deursen at the Mayo Clinic in 2011, Senolytics have shown the greatest promise for anti-aging treatments. As we age, our body accumulates damaged cells called senescent, which send out signal molecules, which in turn alters our biochemistry to a toxic and pro-inflammatory state. The damage caused by these cells is significant, despite their small number. Van Deursen demonstrated that removing these cells alone could increase the lifespan of mice by up to 25%. He did this with a trick. He used genetically modified mice that had self-destruct switches built into the senescent cell.
The race then began to find chemicals that could do the same without the genetically-engineered self destruction. The agents must kill only senescent senescent while leaving the rest of the cells untouched. Even a small amount of residual toxicity can cause serious damage to normal cells. Prior to last week, FOXO4DRI or a combination with quercetin and dasatinib were the best candidates.
I have written (here and here) that senolytics are our best chance for a short-term boost on the road to antiaging medicine.