Exploring TIGIT’s Role as a Therapeutic Target and Biomarker for T-Cell Senescence

TIGIT is a biomarker of T cell senescence and exhaustion

Researchers in a recent study propose that TIGIT may be a marker for T cell senescence or exhaustion within the immune system. TIGIT is not just a biomarker; it’s also a possible therapeutic target. As the research team discovered, lowering TIGIT levels resulted to the restoration of lost function in T-cell populations that experienced high levels of exhaustion and senescence.

Researchers in a recent study propose that TIGIT may be a marker for T cell senescence or exhaustion within the immune system[1]. TIGIT is not just a biomarker; it’s also a possible therapeutic target. As the research team discovered, lowering TIGIT levels resulted to the restoration of lost function in T-cell populations that experienced high levels of exhaustion and senescence.

The aging process is linked to immune dysfunction and T-cell defects. This leads to an increased susceptibility for various diseases. In previous studies, T cells from aged mouse models expressed multiple inhibitory receptors. This provided evidence for the link between T-cell exhaustion (and T-cell senescence). In this study we found that the T-cell immunoglobulin-based inhibitory motif domain (TIGIT), which is a novel coinhibitory receptor for CD8+ T cells in elderly adults, was upregulated. The TIGIT+CD8+ T cells of elderly adults expressed high levels other inhibitory receptors, including PD-1, and exhibited exhaustion features such as a downregulation of CD28 (the key costimulatory cell receptor), representative intrinsic transcriptional control, low production cytokines and heightened susceptibility for apoptosis. TIGIT knockdown reversed their functional defects related to aging.

Source:
https://www.leafscience.org/tigit-as-a-biomarker/

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