Exploring the Intestinal Transport of Mercury Ions Using a Gut-on-a-Chip Device

Gut-on-a chip device for investigating the intestinal transport of ions of mercury

Animal models and static cultures can be used to study the transport of mercury ions through intestinal epithelial cell walls for toxicology assessment. The concepts, however, do not replicate the conditions of the microenvironment in the human gut to monitor the cell physiology in situ. The mechanism of mercury transportation in the human intestinal tract is not known.

A new report published by Nature Microsystems and Nanoengineering describes the development of a gut on a chip instrument that integrates transepithelial electric resistance (TEER), electrochemical sensors, and other sensors.

They suggested exploring the dynamic concept in order to simulate the physical barrier of the intestinal tract and to mirror the biological transport and adsorption mechanism of mercury ions. Scientists recreated the microenvironment of cells by using fluid shear stress, cyclic mechanical force and mechanical strain.


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