Exploring autophagy: The biological clean-ups that could combat age-related disease

The biological cleaning that can combat age-related diseases

Autophagy can be compared to the trash-management system of a cell. Just as municipal waste management involves collection, transport and disposal, the autophagy process of a cell must follow a coordinated multi-step procedure. The first step is to bag up the cellular waste inside phagophores, which are sack-like structures. The autophagosomes mature into cargo containers, called lysosomes. The waste products are only broken down after this.

It is possible for any part of the cell-cleaning to go wrong. This happens a lot as cells age. If researchers don’t fully understand which aspects of autophagy is defective in a particular disease, drugs modulating the wrong parts could cause more harm than good. One therapy might, for example, encourage the cell to accumulate more trash. Tim Sargeant studies autophagy in Adelaide. \”That’s a danger.\”

Some anti-aging researchers and companies are focusing on autophagy. Others, however, are being more circumspect, especially in light of the lack of evidence for the interventions proposed, whether it is based on human or mouse models.

Source:
https://www.nature.com/articles/d41586-022-00075-w

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