Explore the Potential of Melittin and Bee Venom for Cancer Therapy

Melittin is a major component of bee-venom peptides and its conjugates are used in cancer therapy

Melittin, a major component of bee-venom peptides, is a promising candidate for cancer treatment. This agent has demonstrated a range of anti-cancer properties in preclinical animal and cell culture models. Although it has shown a variety of anti-cancer effects in preclinical cell culture and animal model systems, its application to humans is still a challenge due to a number of issues, including non-specific hemolysis, degradation, and cytotoxicity. To overcome these issues, several optimization techniques have been used including the use of nanoparticle-based MEL delivery. We summarize here the current understanding of anticancer effects bee venom, and MEL have on different types of cancers. We also provide information on the possible mechanisms of action for bee venom or MEL.

Keywords: Melittin, Melittin-conjugates, Cancer management.

Cancer is a major disease that affects the human race and continues to be one of the top causes of death worldwide. According to the current data, over 10 million people are diagnosed every year with cancer and more than 6 million die from it. This represents roughly 12% worldwide. In 2020, 15 million new cases of cancer are expected to be diagnosed [1]; this number could increase to 20 million in 2025 [2] or even more in future years. The growth and ageing of the population is expected to increase the number of new cancer cases up to 21,7 million, with approximately 13 million cancer-related deaths by 2030 [3].


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