Explore the link between age-related DNA modifications and susceptibility to eye disease

Researchers have linked age-related changes in DNA to the susceptibility to eye diseases

Researchers at the National Eye Institute (NEI), who profiled epigenomic differences in mouse photoreceptors that detect light, have a better understanding of how age related eye diseases could be linked to changes in gene expression regulation. These findings, which were published in Cell Reports on April 21, suggest that targeting the epigenome as a therapeutic approach could help prevent vision loss caused by age-related macular disease (AMD). NEI is a part of the National Institutes of Health.

Our study clarifies the molecular and biological changes that are linked to the aging of retinal rod photoreceptors. The next step is to investigate how we can delay or prevent vision loss as we age and reduce the risk associated with neurodegeneration.

Every organism is born with its own genome, which is a collection of genes that controls all the functions of cells and tissues in the body. The epigenome of the organism modulates and maintains gene expression, when information in DNA is translated into instructions to make proteins or other molecules. The epigenome tags DNA codes to alter gene expression. This can be beneficial or unfavorable.

Source:
https://medicalxpress.com/news/2020-04-link-age-related-dna-modifications-susceptibility.html

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