Explore the Complexity in Senescent Cells – From Caloric Restriction To Autophagy

The heterogeneity of Senescent cells

Leonard Hayflick & Paul Moorhead discovered cellular senescence in 1961. Cells no longer function and emit harmful chemicals, which cause other cells to become senescent. Senescence is caused primarily by DNA damage and telomeres shortening. It has been shown that senescent cell contributes to many diseases such as Alzheimer’s and Parkinson’s.

Caloric restriction is one way to remove senescent cell. This is done by temporarily reducing the amount of calories in your diet. It has been proven to be the most effective way to slow down the onset and decrease the severity of aging symptoms [1].

Autophagy is a natural way for cells to break down their own parts when they don’t have access to food. Autophagy is known to promote and prevent senescence. It removes macromolecules and organelles such as mitochondria that would otherwise lead to cellular senescence. Some of the autophagy processes can also cause cellular senescence [3].


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