DNA Damage Causes Genome-wide Transcriptional Stress in Aging Mice

The transcriptome changes with age due to RNA polymerase stalling in the genome

In aged mouse livers 40% of elongating polymerases have stalled. This leads to a transcriptional output that is biased by gene length. This transcriptional stress is caused by DNA damage.

Source:
https://www.nature.com/articles/s41588-022-01279-6

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