Discovering the remarkable longevity of mitochondrial proteins

Northwestern scientists find a subset mitochondrial proteins that can help you live a long life

Northwestern Medicine researchers have discovered that the mitochondrial complex of brain and heart cell cells contains a subset which is long-lived. This supports long-term stability.

Jeffrey Savas, Ph.D., assistant professor at the Ken & Ruth Davee Department of Neurology in the Division of Behavioral Neurology and Medicine in the Division of Nephrology and Hypertension and of Pharmacology, led the study.

Savas’s previous work revealed that the complex proteins of nuclear pore in post-mitotic neuronal cells are extraordinarily long-lived, persisting for months in the brains of mice and rats. These proteins are called long-lived protein or LLPs. They provide stability and structure for the nuclear pore, and subsequently the nuclear envelope, of neurons. This concept was not considered before.


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