Discovering the link between age-dependent senescence and neurodegeneration

Astrocyte Senescence leads to neurotoxicity

Researchers from Hebrew University, Hadassah Medical School and Tel Aviv University conducted a study on astrocytes of mice. They found that the cells displayed a senescent-like phenotype, which led to neurodegeneration.

Increase in the number of senescent cells adjacent to Ab plaques with age

Leonard Hayflick, Paul Moorhead and others discovered cellular senescence in 1961. This is the state where cells cease to function and emit harmful chemicals, which turn other cells into senescent… Telomere shortening, DNA damage and other factors are responsible for these cells, and they have been linked to neurodegeneration in many studies.


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