Discovering the genes behind stem cell aging: the GATA6/SHH/FOXP1 pathway

The genes that regulate stem cell aging have been identified

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The gene responsible for stem cell aging was identified.

Above – As mesenchymal stromal/stem cells (MSCs), age, GATA6 transcription factor is produced more in the cell. This leads to an aging response. Transcriptional factor-based cellular reprograming rejuvenates aged MSCs by reducing GATA6’s effects on cellular ageing. CREDIT AlphaMed Press

Researchers at the University of Wisconsin-Madison found that GATA6, which plays a key role in the development of the gut, lungs and heart, was suppressed in the reprogrammed compared to control cells. This repression resulted in an increase of activity for a protein necessary to embryonic development, called sonic Hedgehog (SHH), as well as an expression level of another protein, FOXP1, which is essential for the proper development of brain, heart, and lung. Dr. Li stated that the GATA6/SHH/FOXP1 pathways are key mechanisms for MSC rejuvenation and aging.


Genes for Regulating Stem Cell Aging Identified

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