Discovering human genes that promote senescence: Exploring the potential of gene therapy for extending life expectancy

Scientists Develop New Gene Therapy Strategy To Delay Aging And Extend Lifespan

Cellular senescence – a permanent state of growth arrest – has been identified as the hallmark and primary driver of organismal ageing. Both genetic and epigenetic influences are responsible for its regulation. The identity and role of other genes that are involved in the regulation human cellular ageing remain unknown despite a few genes previously being reported as aging-associated. There is still a lack in systematic research on these genes’ intervention to treat aging or aging-related disease.

How many genes that promote aging are present in the human genome What are the molecular mechanisms through which these genes regulate ageing? Can gene therapy reduce individual aging symptoms? Researchers from the Chinese Academy of Sciences shed light on the regulation of ageing.

Researchers from the Institute of Zoology of Chinese Academy of Sciences, Peking University and Beijing Institute of Genomics of CAS collaborated recently to identify new human senescence promoting genes using a genome wide CRISPR/Cas9 screen system. This collaboration has provided a new therapeutic treatment for aging and aging related pathologies.


Scientists Develop New Gene Therapy Strategy to Delay Aging and Extend Lifespan

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