Discovering CRELD1’s role in protecting the immune system from aging

The immune system is protected from aging by genetic disposition

The same genetic disposition that is involved in the development and function of the heart during embryonic development also seems to be important for the immune system in humans. A recent study conducted by the University of Bonn in Germany has shown this. The immune system becomes less effective when the gene isn’t active enough. Doctors often refer to an aging immunity system because a similar effect is observed in older individuals. The results could help reduce age-related loss in the medium term. The study was published in Nature Immunology.

Science has been puzzled by the gene CRELD1 until now. It was well known that it played a crucial role in the heart development in the embryo. CRELD1 is still active after birth. Studies have shown that it’s produced regularly in virtually all the cells of the human body. But, until recently, it was not known what the purpose of CRELD1 is.

Researchers at Bonn used a novel method to answer this question. In modern scientific studies involving human participants, so-called transcriptome analysis is often included. Using these methods, it is possible to determine the extent of gene activity in a test subject. Researchers increasingly share the data that they collect with colleagues so that they can use it for completely different purposes. \”And that is exactly what we have done in our study,\” said Dr. Anna Aschenbrenner, from the LIMES Institute of the University of Bonn. She is a member of ImmunoSensation2 Cluster of Excellence.


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