Delaying aging and extending life span in mice with the eNAMPT Salvage Pathway and NAD

ENAMPT delays aging and extends life expectancy in mice

Researchers at Washington University School of Medicine, St. Louis, have found a way to slow down the aging process in mice by using a protein which is present in abundance in young mice’s blood but decreases as they age.

The NAD and eNAMPT salvage pathway

That protein is extracellular nicotinamide phosphoribosyltransferase (eNAMPT), and it plays a key role in the process that cells use to create nicotinamide adenine dinucleotide (NAD), a crucial component that they need for energy production. NAD is found in every living cell. It is a DINUCLEOTIDE, meaning that it is made up of two nucleotides linked by their phosphate group. The nucleotide consists of two bases: adenine and nicotinamide.


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