Cellular Senescence and Old Blood

Does old blood cause senescence in humans?
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In 2005, a landmark study showed that merging the blood systems of young and old mice, also known as heterochronic parbiosis rejuvenated old mice’s cells. The study suggested that something was in the blood. There were two possible explanations: there were rejuvenating agents in the young blood or there was a dilution in pro-aging hormones in the old blood. Or a combination of the two.

Since 2005, more studies have been published. In 2016, a study found that heterochronic exchanges, which is just transferring blood from old to young or young to old without fusing it, had greater effects when the old blood was transferred to the young. Better put, \”the inhibitory effect of old blood is more pronounced than benefits of young\”.

This would rule out the \”factors of young blood\”. This theory was also supported by studies that were published in the past. The same result was achieved by simply diluting old blood (removing plasma from the blood of old mice) and replacing it albumin and saline. This process is called neutral plasma exchange and does not involve any Frankenstein surgery. AMAZING.

It didn’t say why or how. They left us this interesting hypothetical hypothesis chart of what could potentially happen to certain factors in the blood. However, they weren’t sure what or how those beneficial effects were achieved. What were the most important factors to eliminate?

Now we have more answers. First, we must introduce cellular senescence.

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