Biomimicry and Evolution: A Novel 5MCAR-T Cell for Immunotherapy Treatments in Autoimmune Diseases

The use of genetically engineered T-cells could be a treatment for autoimmune disorders

Researchers at the University of Arizona Health Sciences have found that a genetically modified T cell can target and destroy pathogenic T-cells that cause Type 1 Diabetes. This could lead to the development of new immunotherapy treatment.

Immune system uses T cells that have specific receptors to fight bacteria, viruses, and other pathogens. The receptor on killer T cells works with three signaling module and a coreceptor in order to destroy the infected cells. Michael Kuhns Ph.D. is an associate professor at the UArizona College of Medicine – Tucson Department of Immunobiology. He copied the evolutionary design in order to engineer a T cell with a 5-module chimeric receptor.

The 5MCAR was a biomimicry experiment to see if we can build something using evolution’s natural components and re-direct T cells so that they do what we desire. We created a 5MCAR to direct killer T-cells towards autoimmune T-cells that are responsible for Type 1 diabetes,\” explained Dr. Kuhns. He is a member of the UArizona Cancer Center BIO5 Institute, and Arizona Center on Aging. Now, a killer cell will recognize another cell. We turned T cell-mediated immune system on its head.

Source:
https://medicalxpress.com/news/2020-12-genetically-cells-therapies-autoimmune-diseases.html

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