Accelerated Aging of the Eye: How Repeated Stress Causes Epigenetic and Transcriptional Changes in Retinal Tissue

A new study has shown that repeated stress can accelerate the aging process of the eyes
Researchers at the University of California Irvine have found that aging plays a significant role in retinal ganglion cells dying from glaucoma. They also discovered novel pathways to target when developing new treatments for patients with glaucoma.

The study has been published in Aging Cell today. Dorota Skorronska-Krawczyk Ph.D. and her colleagues from the UCI School of Medicine’s Center for Translational Vision Research describe the epigenetic and transcriptional changes occurring in aging retina.

The team shows that stress, like intraocular pressure elevation (IOP), causes retinal tissues to undergo epigenetic changes and transcriptional modifications similar to natural ageing. In young retinal tissues, repeated stress induces features such as accelerated epigenetic aging.


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